Tax-loss harvesting alternatives for XBI

The closest fund alternative to XBI (Biotechnology (Equal Wt)) is IBB (iShares Biotechnology ETF), with a return correlation of 0.91 over the past year. Among single names in the fund's slice of the market, KRYS (Krystal Biotech) tracks it most closely at 0.49 over the past year. Correlations are computed from daily closing-price returns aligned by trading day.

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ETFS

Fund stand-ins

Funds covering similar ground. Two funds tracking the same index may themselves be 'substantially identical' for wash-sale purposes.

Ticker	Name	Focus	Match	1Y	3Y	5Y	10Y
IBB	iShares Biotechnology ETF	Biotechnology	INDUSTRY	0.91	0.91	0.90	0.91
XPH	SPDR S&P Pharmaceuticals	Pharmaceuticals (Equal Wt)	INDUSTRY	0.82	0.80	0.80	0.80
ARKG	ARK Genomic Revolution ETF	Genomics (Active)	INDUSTRY	0.71	0.79	0.84	0.85
IHE	iShares US Pharmaceuticals ETF	Pharmaceuticals	INDUSTRY	0.63	0.63	0.60	0.68
VHT	Vanguard Health Care ETF	Health Care Sector	SECTOR	0.59	0.66	0.66	0.70
FHLC	Fidelity MSCI Health Care ETF	Health Care Sector	SECTOR	0.59	0.65	0.66	0.70
IYH	iShares US Healthcare ETF	Health Care Sector	SECTOR	0.54	0.60	0.60	0.66
PPH	VanEck Pharma ETF	Pharmaceuticals	INDUSTRY	0.48	0.52	0.51	0.60
XLV	Health Care Select Sector SPDR	Health Care Sector	SECTOR	0.48	0.56	0.55	0.61
XHS	SPDR S&P Health Care Services	Health Care Services	INDUSTRY	0.36	0.53	0.65	0.64
IHI	iShares Medical Devices ETF	Medical Devices	SUB-IND	0.25	0.43	0.53	0.59
IHF	iShares Health Care Providers	Health Care Providers	INDUSTRY	0.23	0.31	0.41	0.51

STOCKS

Single-name peers

Single names inside the fund's slice of the market.

Ticker	Name	Sub-industry	1Y	3Y	5Y	10Y
KRYS	Krystal Biotech	Biotechnology	0.49	0.57	0.43	0.42
ARWR	Arrowhead Pharmaceuticals	Biotechnology	0.48	0.57	0.66	0.55
CYTK	Cytokinetics	Biotechnology	0.47	0.42	0.48	0.46
EXEL	Exelixis	Biotechnology	0.43	0.34	0.42	0.53
BMRN	BioMarin Pharmaceutical	Biotechnology	0.43	0.47	0.53	0.57
INCY	Incyte	Biotechnology	0.42	0.46	0.45	0.52
AMGN	Amgen Inc.	Biotechnology	0.40	0.42	0.35	0.45
HRMY	Harmony Biosciences Holdings, Inc.	Biotechnology	0.35	0.34	0.41	—
HALO	Halozyme	Biotechnology	0.35	0.41	0.46	0.54
FTRE	Fortrea	Biotechnology	0.35	0.38	0.37	—
BIIB	Biogen Inc.	Biotechnology	0.32	0.45	0.46	0.42
GILD	Gilead Sciences	Biotechnology	0.32	0.35	0.34	0.40
ALNY	Alnylam Pharmaceuticals	Biotechnology	0.29	0.38	0.44	0.50
ADMA	ADMA Biologics, Inc.	Biotechnology	0.29	0.40	0.48	0.37

NEXT STEPS

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Replacement research for XBI's peers

KRYS ARWR CYTK EXEL BMRN INCY AMGN HRMY HALO FTRE BIIB GILD ALNY ADMA

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Method: Pearson correlation of daily closing-price returns, Yahoo Finance data, series aligned by trading day, refreshed weekly. A cell is blank when overlapping history covers less than 60% of its window. Correlation is descriptive, not predictive. Wash-sale treatment depends on facts and circumstances — confirm with a tax professional. Not investment advice.