Tax-loss harvesting alternatives for VRTX

Among the 28 Biotechnology peers screened, AMGN (Amgen Inc.) has tracked VRTX most closely over the past year, with a return correlation of 0.53. The strongest fund stand-in is IBB (iShares Biotechnology ETF) at 0.67 over the past year. Correlations are computed from daily closing-price returns aligned by trading day.

Run this search live in the Screener →

STOCKS

Single-name peers

Ticker	Name	Sub-industry	1Y	3Y	5Y	10Y
AMGN	Amgen Inc.	Biotechnology	0.53	0.39	0.38	0.44
GILD	Gilead Sciences	Biotechnology	0.48	0.34	0.37	0.40
BIIB	Biogen Inc.	Biotechnology	0.48	0.35	0.35	0.32
INCY	Incyte	Biotechnology	0.43	0.33	0.36	0.44
REGN	Regeneron Pharmaceuticals	Biotechnology	0.42	0.36	0.39	0.46
BMRN	BioMarin Pharmaceutical	Biotechnology	0.41	0.27	0.32	0.41
HALO	Halozyme	Biotechnology	0.38	0.22	0.24	0.30
VIR	Vir Biotechnology, Inc.	Biotechnology	0.34	0.25	0.23	0.12
EXEL	Exelixis	Biotechnology	0.33	0.20	0.23	0.34
SRPT	Sarepta Therapeutics	Biotechnology	0.30	0.23	0.24	0.27
KRYS	Krystal Biotech	Biotechnology	0.30	0.26	0.22	0.23
ALNY	Alnylam Pharmaceuticals	Biotechnology	0.29	0.21	0.22	0.29
NBIX	Neurocrine Biosciences	Biotechnology	0.29	0.21	0.25	0.35
MRNA	Moderna Inc.	Biotechnology	0.29	0.22	0.21	0.18
CYTK	Cytokinetics	Biotechnology	0.28	0.17	0.19	0.23
XNCR	Xencor Inc	Biotechnology	0.26	0.25	0.27	0.31
RCUS	Arcus Biosciences, Inc.	Biotechnology	0.25	0.23	0.22	0.24
VCEL	Vericel	Biotechnology	0.24	0.23	0.22	0.23
ARWR	Arrowhead Pharmaceuticals	Biotechnology	0.24	0.26	0.28	0.26
TGTX	TG Therapeutics, Inc.	Biotechnology	0.23	0.19	0.21	0.24
RGEN	Repligen	Biotechnology	0.23	0.22	0.22	0.30
LGND	Ligand Pharmaceuticals, Inc.	Biotechnology	0.21	0.20	0.21	0.30
HRMY	Harmony Biosciences Holdings, Inc.	Biotechnology	0.20	0.13	0.18	0.14
PTGX	Protagonist Therapeutics, Inc.	Biotechnology	0.19	0.19	0.15	0.13
FTRE	Fortrea	Biotechnology	0.19	0.19	0.18	—
ADMA	ADMA Biologics, Inc.	Biotechnology	0.18	0.20	0.21	0.15
ROIV	Roivant Sciences	Biotechnology	0.18	0.22	0.21	—
UTHR	United Therapeutics	Biotechnology	0.17	0.17	0.24	0.29

ETFS

Fund stand-ins

An ETF is generally not 'substantially identical' to a single stock, which is why funds are the standard wash-sale-aware replacement.

Ticker	Name	Focus	Match	1Y	3Y	5Y	10Y
IBB	iShares Biotechnology ETF	Biotechnology	INDUSTRY	0.67	0.56	0.56	0.61
IYH	iShares US Healthcare ETF	Health Care Sector	SECTOR	0.66	0.51	0.53	0.57
FHLC	Fidelity MSCI Health Care ETF	Health Care Sector	SECTOR	0.65	0.51	0.53	0.57
VHT	Vanguard Health Care ETF	Health Care Sector	SECTOR	0.65	0.51	0.53	0.57
XLV	Health Care Select Sector SPDR	Health Care Sector	SECTOR	0.64	0.50	0.52	0.56
PPH	VanEck Pharma ETF	Pharmaceuticals	INDUSTRY	0.59	0.45	0.48	0.51
IHE	iShares US Pharmaceuticals ETF	Pharmaceuticals	INDUSTRY	0.58	0.45	0.47	0.52
XBI	SPDR S&P Biotech ETF	Biotechnology (Equal Wt)	INDUSTRY	0.49	0.42	0.41	0.50
XPH	SPDR S&P Pharmaceuticals	Pharmaceuticals (Equal Wt)	INDUSTRY	0.42	0.37	0.40	0.46
IHI	iShares Medical Devices ETF	Medical Devices	SUB-IND	0.35	0.28	0.35	0.44
ARKG	ARK Genomic Revolution ETF	Genomics (Active)	INDUSTRY	0.34	0.30	0.32	0.40
IHF	iShares Health Care Providers	Health Care Providers	INDUSTRY	0.25	0.22	0.31	0.38

NEXT STEPS

Harvesting a loss in VRTX?

Estimate what the harvest could save →Check the eight wash-sale traps →Document the trade with a Tax Memo →

Replacement research for VRTX's peers

AMGN GILD BIIB INCY REGN BMRN HALO VIR EXEL SRPT KRYS ALNY NBIX MRNA CYTK XNCR RCUS VCEL ARWR TGTX RGEN LGND HRMY PTGX FTRE ADMA ROIV UTHR

Browse all tickers →

Method: Pearson correlation of daily closing-price returns, Yahoo Finance data, series aligned by trading day, refreshed weekly. A cell is blank when overlapping history covers less than 60% of its window. Correlation is descriptive, not predictive. Wash-sale treatment depends on facts and circumstances — confirm with a tax professional. Not investment advice.